Lets assume that you are looking for TreeSize alternative in the Linux world. There are a few disk usage/cleanup tools available under GNome or KDE.
If you have some time, then cleaning up your home directory is pretty simple on the command line:
Assume you want to clean your /home directory.
$> du -H /home > cleanfile
Now when you open cleanfile in your text editor, you should see the files/directories. Looking at the directory names should tell you whether you need those dirs or now.